Updated: Jul 31, 2026
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| Section | Weight | Objectives |
|---|---|---|
| Healthcare Systems and Population Health | 10% | - Population-based pharmacotherapy - Healthcare delivery models - Regulatory and economic considerations - Medication safety and quality improvement |
| Patient-Centered Pharmacotherapy | 65% | - Pathophysiology and clinical presentation - Adverse drug reactions and interactions - Therapeutic guidelines and evidence-based treatment - Drug selection, dosing, and monitoring - Pharmacokinetics and pharmacodynamics |
| Application of Evidence to Practice and Education | 25% | - Patient education and counseling - Literature evaluation and biostatistics - Drug information and communication - Clinical research and guideline development |
1. A 25-year-old woman who is HIV-positive and has a CD4+ count of 120 cells/mm begins antiretroviral therapy. The patient's CD4+ count drops to 45 cells/mm3 over the next year. For which of the following opportunistic infections should this patient receive prophylaxis?
A) MAC and Pneumocystis jirovecii pneumonia
B) MAC and Candida
C) Mycobacterium tuberculosis and Pneumocystis Jirovecii pneumonia
D) Mycobacterium tuberculosis and CMV
2. A 46-year-old man comes into the clinic complaining of facial swelling and difficulty breathing.
Upon examination, it is determined that the patient has facial edema most likely associated with enalapril use. The patient was transferred to the hospital for treatment of the facial edema. It is most appropriate to report this reaction to the:
A) FDA.
B) MEDMARX database.
C) Drug manufacturer.
D) Vaccine Adverse Event Reporting System.
3. A 49-year-old patient has been taking pregabalin for the treatment of fibromyalgia for one year with good relief of symptoms. However, this patient recently lost access to health insurance.
Although she experienced excellent relief from pregabalin, she is unable to continue this therapy due to cost.
Which of the following would be the best intervention?
A) Change to gabapentin
B) Change to tramaddy
C) Change to amitriptyline
D) Change to duloxetine
4. A pharmacotherapy specialist has been asked to provide information on the incidence of a particular side effect for a drug that has now been on the U.S. market for 5 years. The only information available comes from the FDA's MedWatch program. The apparent incidence of a given adverse effect, as determined from the MedWatch database, is likely to be which of the following?
A) Unreliable because the voluntary nature of reporting makes numerator data questionable
B) Unreliable because reporting healthcare providers usually fail to establish a temporal relationship
C) Reliable because healthcare institutions such as hospitals are mandated to report all adverse drug events to the FDA
D) Reliable because the data are accumulated in cooperation with the pharmaceutical industry
5. A 50-year-old patient has a past medical history significant for obesity. The patient has no family history of coronary artery disease, does not smoke or drink, and presently takes only aspirin 81 mg daily. Today's fasting lipid panel is:
Total cholesterol: 230 mg/dL
HDL cholesterol: 45mg/dL
LDL cholesterol: 140 mg/dL
Triglycerides: 160 mg/dL
The patient's ASCVD 10-year risk score is equal to 4%. According to the ACC/AHA, what is the most appropriate intervention?
A) Niacin extended-release 500 mg once daily
B) Fenofibrate 160 mg daily
C) Atorvastatin 40 mg daily
D) Group weight-loss program
Solutions:
| Question # 1 Answer: A | Question # 2 Answer: A | Question # 3 Answer: D | Question # 4 Answer: C | Question # 5 Answer: C |
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